PATHOLOGIC HISTOLOGY OF THE SHWARTZMAN PHENOMENON WITH INTERPRETATIVE COMMENTS

Pathologic Histology of the Shwartzman Phenomenon with Interpretative Comments

The histological study of the reaction to injection of the preparatory factor of the Shwartzman phenomenon shows it to be an exudative inflammation, but furnishes no conclusive evidence as to whether or not the inflammation is conditioned by previous sensitization to substances contained in the bacterial filtrate. The histological study of the local reaction which follows the intravenous inject...

Inhibition of the Shwartzman Phenomenon

The Shwartzman phenomenon can be inhibited by an intravenous injection of a potent bacterial filtrate within a few hours before or after the preparatory intradermal injection. The inhibitory effect is produced non-specifically by filtrates potent in the elicitation of the Shwartzman phenomenon, and it is of a transitory nature. The relation of the observation described to anaphylactic desensiti...

Platelets and the Shwartzman Phenomenon

Studies are reported on the effect of immunologically induced thrombocytopenia upon the local and generalized Shwartzman phenomena. Intravenous injection of antiplatelet serum to rabbits produced profound but transient thrombocytopenia unaccompanied by significant changes in circulating leucocytes. Platelet antiserum alone given to rabbits prepared with thorotrast produced renal lesions charact...

Studies on the Shwartzman Phenomenon

Formalin induces a considerable change in meningococcus culture filtrates. This consists of a marked decrease in toxidty as concerns both the Shwartzman phenomenon and the lethal effect, with relative preservation of the antibody-combining capacity and antigenicity. A similar modification occurs spontaneously in meningococcus culture filtrates on standing. Inasmuch as these changes parallel tho...

The generalized Shwartzman phenomenon in rats.